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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552733
Species: Mus musculus
RGD Object: Gene
Symbol: Pou5f1
Name: POU domain, class 5, transcription factor 1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pou5f1decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of POU5F1 mRNA; Arsenic Trioxide results in decreased expression of POU5F1 proteinPMID:29767511
Pou5f1multiple interactionsEXP 6480464CTD[Arsenic Trioxide co-treated with FN1 protein] results in decreased expression of POU5F1 mRNAPMID:22641096
Pou5f1decreases expressionISOPOU5F1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of POU5F1 mRNAPMID:33634982
Pou5f1increases expressionISOPOU5F1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of POU5F1 mRNA; Arsenic Trioxide results in increased expression of POU5F1 proteinPMID:29396848 PMID:29486283
Pou5f1multiple interactionsISOPOU5F1 (Homo sapiens)6480464CTDArsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of POU5F1 protein]; EIF2AK2 protein affects the reaction [Arsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of POU5F1 protein]]; EIF2AK2 protein affects the reaction [Arsenic Trioxide results in increased expression of POU5F1 protein]; EIF2S1 protein affects the reaction [Arsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of POU5F1 protein]]; MSI1 protein affects the reaction [Arsenic Trioxide results in increased expression of POU5F1 protein]; PTGS2 protein affects the reaction [Arsenic Trioxide results in increased expression of POU5F1 protein]; SOX2 protein affects the reaction [Arsenic Trioxide results in increased expression of POU5F1 protein]; SOX2 protein affects the reaction [PTGS2 protein affects the reaction [Arsenic Trioxide results in increased expression of POU5F1 protein]]PMID:29396848 PMID:29486283
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