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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348351
Species: Homo sapiens
RGD Object: Gene
Symbol: ACTA2
Name: actin alpha 2, smooth muscle
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACTA2decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of ACTA2 mRNA; Arsenic Trioxide results in decreased expression of ACTA2 proteinPMID:30317545 PMID:35276128
ACTA2increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of ACTA2 mRNA; Arsenic Trioxide results in increased expression of ACTA2 proteinPMID:30677399 PMID:32240679
ACTA2multiple interactionsEXP 6480464CTD3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein]; Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; MK-886 inhibits the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein]; NFE2L2 protein affects the reaction [Arsenic Trioxide results in decreased expression of ACTA2 protein]; PML protein affects the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein]; RNF4 protein affects the reaction [Arsenic Trioxide results in increased expression of ACTA2 mRNA]; Taurine inhibits the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein]; UBE2I protein affects the reaction [Arsenic Trioxide results in increased expression of ACTA2 mRNA]PMID:24762191 PMID:30317545 PMID:30677399 PMID:32240679 PMID:35276128
ACTA2increases expressionISOActa2 (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of ACTA2 proteinPMID:30677399
ACTA2multiple interactionsISOActa2 (Mus musculus)6480464CTD[Arsenic Trioxide co-treated with Bleomycin] results in decreased expression of ACTA2 mRNA; Taurine inhibits the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein]PMID:24762191 PMID:30677399
ACTA2multiple interactionsISOActa2 (Rattus norvegicus)6480464CTD[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of ACTA2 mRNA]; Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of ACTA2 mRNA]; Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]; Arsenic Trioxide promotes the reaction [Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]]; Curcumin promotes the reaction [Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]]PMID:31612257
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