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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318375
Species: Mus musculus
RGD Object: Gene
Symbol: Sirt1
Name: sirtuin 1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt1decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of SIRT1 mRNA; Arsenic Trioxide results in decreased expression of SIRT1 proteinPMID:36707890
Sirt1multiple interactionsEXP 6480464CTDMIR34A affects the reaction [Arsenic Trioxide results in decreased expression of SIRT1 protein]; Propranolol inhibits the reaction [Arsenic Trioxide results in decreased expression of SIRT1 mRNA]; Propranolol inhibits the reaction [Arsenic Trioxide results in decreased expression of SIRT1 protein]PMID:36707890
Sirt1decreases expressionISOSirt1 (Rattus norvegicus)6480464CTDArsenic Trioxide results in decreased expression of SIRT1 proteinPMID:33173984
Sirt1decreases expressionISOSIRT1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of SIRT1 mRNAPMID:19763917
Sirt1increases expressionISOSirt1 (Rattus norvegicus)6480464CTDArsenic Trioxide results in increased expression of SIRT1 proteinPMID:31332900
Sirt1multiple interactionsISOSirt1 (Rattus norvegicus)6480464CTDMetformin promotes the reaction [Arsenic Trioxide results in increased expression of SIRT1 protein]; trans-sodium crocetinate inhibits the reaction [Arsenic Trioxide results in decreased expression of SIRT1 protein]PMID:31332900 PMID:33173984
Sirt1multiple interactionsISOSIRT1 (Homo sapiens)6480464CTDArsenic Trioxide promotes the reaction [NVP-BKM120 results in decreased expression of SIRT1 mRNA]PMID:30316766
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