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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309424
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ncf2
Name: neutrophil cytosolic factor 2
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationISORGD:13197606480464CTDArsenic Trioxide affects the localization of NCF2 protein

PMID:18424721, PMID:22532027
increases expressionISORGD:13197606480464CTDArsenic Trioxide results in increased expression of NCF2 mRNA, Arsenic Trioxide results in increased expression of NCF2 protein

PMID:15070760, PMID:22532027
increases expressionISORGD:13197616480464CTDArsenic Trioxide results in increased expression of NCF2 protein

PMID:27638049
multiple interactionsISORGD:13197606480464CTDNCF2 mutant form inhibits the reaction [Arsenic Trioxide results in increased abundance of Reactive Oxygen Species], NCF2 mutant form inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein], NCF2 mutant form inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of EGFR protein]

PMID:22532027
multiple interactionsISORGD:13197616480464CTDATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of NCF2 protein]

PMID:27638049
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.