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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305471
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atf6
Name: activating transcription factor 6
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf6decreases expressionISOATF6 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of ATF6 proteinPMID:23883479
Atf6increases expressionISOATF6 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of ATF6 mRNA; Arsenic Trioxide results in increased expression of ATF6 proteinPMID:17963750 PMID:19176121 PMID:25107562 PMID:25258189
Atf6increases expressionISOAtf6 (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of ATF6 mRNAPMID:23892647 PMID:34091186
Atf6increases phosphorylationISOATF6 (Homo sapiens)6480464CTDArsenic Trioxide results in increased phosphorylation of ATF6 proteinPMID:34560123
Atf6multiple interactionsISOATF6 (Homo sapiens)6480464CTDArsenic Trioxide promotes the reaction [nilotinib results in decreased expression of ATF6 protein]; Resveratrol inhibits the reaction [Arsenic Trioxide results in increased expression of ATF6 protein]PMID:23883479 PMID:25107562
Atf6multiple interactionsISOAtf6 (Mus musculus)6480464CTD1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased cleavage of ATF6 protein]; [Arsenic Trioxide co-treated with antimony trichloride] results in increased expression of ATF6 mRNA; [Arsenic Trioxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased cleavage of ATF6 protein; Arsenic Trioxide results in increased expression of and results in increased cleavage of ATF6 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased cleavage of ATF6 protein]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of ATF6 mRNA]PMID:23892647 PMID:34091186
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