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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10816
Species: Mus musculus
RGD Object: Gene
Symbol: Irs1
Name: insulin receptor substrate 1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Irs1affects response to substanceISOIRS1 (Homo sapiens)6480464CTDIRS1 mRNA affects the susceptibility to Arsenic TrioxidePMID:23911876
Irs1decreases expressionISOIRS1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of IRS1 mRNAPMID:20458559
Irs1increases phosphorylationISOIRS1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased phosphorylation of IRS1 proteinPMID:30362509
Irs1multiple interactionsISOIRS1 (Homo sapiens)6480464CTD3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of IRS1 protein]; Palmitic Acid inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of IRS1 protein]; Rosiglitazone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of IRS1 protein]; Taurine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of IRS1 protein]PMID:30362509
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