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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2674
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gdf15
Name: growth differentiation factor 15
Acc ID: CHEBI:49703
Term: latrunculin B
Definition: A macrolide consisting of a 14-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica.
Chemical ID: MESH:C037068
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gdf15increases expressionISOGDF15 (Homo sapiens)6480464CTDlatrunculin B results in increased expression of GDF15 mRNA; latrunculin B results in increased expression of GDF15 proteinPMID:23996089
Gdf15multiple interactionsISOGDF15 (Homo sapiens)6480464CTD[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [latrunculin B results in increased expression of GDF15 protein]PMID:23996089
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