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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 14111954
Species: Sus scrofa
RGD Object: Gene
Symbol: FES
Name: FES proto-oncogene, tyrosine kinase
Acc ID: CHEBI:49668
Term: gefitinib
Definition: A member of the class of quinazolines that is quinazoline which is substituted by a (3-chloro-4-fluorophenyl)nitrilo group, 3-(morpholin-4-yl)propoxy group and a methoxy group at positions 4,6 and 7, respectively. An EGFR kinase inhibitor used for the treatment of non-small cell lung cancer.
Chemical ID: MESH:C419708
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FESdecreases phosphorylationEXP 6480464CTDGefitinib results in decreased phosphorylation of FES proteinPMID:19885553
FESmultiple interactionsEXP 6480464CTDGefitinib inhibits the reaction [FGF2 protein results in increased phosphorylation of FES protein]; Gefitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of FES protein]PMID:19885553
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