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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736021
Species: Homo sapiens
RGD Object: Gene
Symbol: APP
Name: amyloid beta precursor protein
Acc ID: CHEBI:49662
Term: indometacin
Definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
APPaffects cleavageEXP 6480464CTDIndomethacin affects the cleavage of APP proteinPMID:11700559
APPmultiple interactionsEXP 6480464CTDIndomethacin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased metabolism of and results in increased secretion of APP protein alternative form]; Indomethacin inhibits the reaction [APP protein alternative form results in increased expression of IL6 protein]PMID:14586007 PMID:16111494
APPdecreases expressionISOApp (Mus musculus)6480464CTDIndomethacin results in decreased expression of APP protein alternative formPMID:15579461 PMID:17627676
APPmultiple interactionsISOApp (Rattus norvegicus)6480464CTDIndomethacin inhibits the reaction [APP protein results in increased uptake of Calcium]PMID:18648507
APPmultiple interactionsISOApp (Mus musculus)6480464CTDIndomethacin inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Indomethacin inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]PMID:11080519
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