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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734432
Species: Mus musculus
RGD Object: Gene
Symbol: Nfe2l2
Name: nuclear factor, erythroid derived 2, like 2
Acc ID: CHEBI:49662
Term: indometacin
Definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2multiple interactionsEXP 6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Rosiglitazone co-treated with Indomethacin] results in increased activity of NFE2L2 proteinPMID:33412187
Nfe2l2affects localizationISONfe2l2 (Rattus norvegicus)6480464CTDIndomethacin affects the localization of NFE2L2 proteinPMID:25110317
Nfe2l2decreases expressionISONfe2l2 (Rattus norvegicus)6480464CTDIndomethacin results in decreased expression of NFE2L2 mRNAPMID:28648817
Nfe2l2increases localizationISONFE2L2 (Homo sapiens)6480464CTDIndomethacin results in increased localization of NFE2L2 proteinPMID:11909699
Nfe2l2multiple interactionsISONfe2l2 (Rattus norvegicus)6480464CTDRanitidine inhibits the reaction [Indomethacin results in decreased expression of NFE2L2 mRNA]; Silymarin inhibits the reaction [Indomethacin results in decreased expression of NFE2L2 mRNA]PMID:28648817
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]]; Acetylcysteine inhibits the reaction [Indomethacin results in increased localization of NFE2L2 protein]; Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]PMID:11909699
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