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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:49662
Term: indometacin
Definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrdecreases activityEXP 6480464CTDIndomethacin results in decreased activity of GSR proteinPMID:12566098 PMID:18181030
Gsrdecreases expressionEXP 6480464CTDIndomethacin results in decreased expression of GSR mRNAPMID:16771604
Gsrmultiple interactionsEXP 6480464CTDAllopurinol inhibits the reaction [Indomethacin results in decreased activity of GSR protein]; LEP protein inhibits the reaction [Indomethacin results in decreased activity of GSR protein]; Zinc inhibits the reaction [Indomethacin results in decreased activity of GSR protein]PMID:12566098 PMID:18181030
Gsrmultiple interactionsISOGSR (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GSR mRNAPMID:28628672
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