GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mpo | increases activity | EXP | | 6480464 | CTD | Indomethacin results in increased activity of MPO protein | PMID:10210152 PMID:10671773 PMID:11148446 PMID:11686837 PMID:11713966 PMID:11855677 PMID:11991626 PMID:12498302 PMID:12566098 PMID:14567935 PMID:15046732 PMID:16113693 PMID:16133968 PMID:16169175 PMID:16328016 PMID:17002672 PMID:17151854 PMID:17202747 PMID:17351913 PMID:17763956 PMID:17895592 PMID:18087811 PMID:18181030 PMID:18209962 PMID:18236018 PMID:18306037 PMID:18726076 PMID:19034656 PMID:19497431 PMID:20361948 PMID:20723003 PMID:23892052 PMID:25926722 PMID:28648817 PMID:37483153 | Mpo | increases expression | EXP | | 6480464 | CTD | Indomethacin results in increased expression of MPO protein | PMID:12024109 PMID:16080005 | Mpo | multiple interactions | EXP | | 6480464 | CTD | 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Allopurinol inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Amiodarone promotes the reaction [Indomethacin results in increased activity of MPO protein]; Ampicillin inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Arginine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Ascorbic Acid inhibits the reaction [Indomethacin results in increased activity of MPO protein]; bis(2-guanidinoethyl)disulfide inhibits the reaction [Indomethacin results in increased activity of MPO protein]; candesartan inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Capsaicin inhibits the reaction [Indomethacin results in increased activity of MPO protein]; cobaltiprotoporphyrin inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Curcumin inhibits the reaction [Indomethacin results in increased activity of MPO protein]; EPO protein inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Famotidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; fucoidan inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Gallic Acid analog inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Indomethacin inhibits the reaction [Capsaicin affects the activity of MPO protein]; Indomethacin inhibits the reaction [capsazepine affects the activity of MPO protein]; Indomethacin inhibits the reaction [COL2A1 results in increased activity of MPO protein]; Indomethacin inhibits the reaction [NPPA protein affects the activity of MPO protein]; Indomethacin inhibits the reaction [Smoke promotes the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]]; Indomethacin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; irsogladine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; lafutidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Lansoprazole inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Mirtazapine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; montelukast inhibits the reaction [Indomethacin results in increased activity of MPO protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Indomethacin results in increased activity of MPO protein]; ONO-AE1-329 inhibits the reaction [Indomethacin results in increased activity of MPO protein]; ONO-NT 012 inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Pantoprazole inhibits the reaction [Indomethacin results in increased expression of MPO protein]; Pentoxifylline inhibits the reaction [Indomethacin results in increased activity of MPO protein]; pimagedine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; pimagedine promotes the reaction [Indomethacin results in increased activity of MPO protein]; Quercetin promotes the reaction [Famotidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]]; Ranitidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; rebamipide inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Rolipram inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Sildenafil Citrate inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Silymarin inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Tacrolimus inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Theophylline inhibits the reaction [Indomethacin results in increased activity of MPO protein]; thiaton inhibits the reaction [Indomethacin results in increased activity of MPO protein]; tianeptine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; TNF protein affects the reaction [Indomethacin results in increased activity of MPO protein]; usnic acid inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Zinc inhibits the reaction [Indomethacin results in increased activity of MPO protein]; zinc protoporphyrin promotes the reaction [Indomethacin results in increased activity of MPO protein] | PMID:10671773 PMID:11137876 PMID:11686837 PMID:11713966 PMID:11855677 PMID:11991626 PMID:12566098 PMID:12893632 PMID:14567935 PMID:16080005 PMID:16113693 PMID:16133968 PMID:16169175 PMID:17151854 PMID:17202747 PMID:17351913 PMID:17522345 PMID:17763956 PMID:17895592 PMID:18087811 PMID:18209962 PMID:18306037 PMID:18726076 PMID:19034656 PMID:19497431 PMID:20723003 PMID:23892052 PMID:25926722 PMID:28648817 PMID:35446470 PMID:37483153 | Mpo | increases activity | ISO | Mpo (Mus musculus) | 6480464 | CTD | Indomethacin results in increased activity of MPO protein | PMID:10567023 PMID:15138204 PMID:16184426 PMID:21691039 PMID:25656915 | Mpo | multiple interactions | ISO | Mpo (Mus musculus) | 6480464 | CTD | (glycyl-glycyl)GLP-2 inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Dexamethasone inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Domperidone inhibits the reaction [Indomethacin results in increased activity of MPO protein]; fucoidan inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Indomethacin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]; Metoclopramide inhibits the reaction [Indomethacin results in increased activity of MPO protein]; rebamipide inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Thalidomide inhibits the reaction [Indomethacin results in increased activity of MPO protein] | PMID:10567023 PMID:15138204 PMID:16184426 PMID:16716910 PMID:21691039 | Mpo | multiple interactions | ISO | MPO (Homo sapiens) | 6480464 | CTD | [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to Indomethacin metabolite; Indomethacin inhibits the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Indomethacin inhibits the reaction [MPO protein results in increased oxidation of dibromoacetonitrile] | PMID:25614581 PMID:28754375 | | ||||||||||||||||||||||
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