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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344624
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCC1
Name: ATP binding cassette subfamily C member 1 (ABCC1 blood group)
Acc ID: CHEBI:49662
Term: indometacin
Definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCC1affects activityEXP 6480464CTDIndomethacin analog affects the activity of ABCC1 proteinPMID:15715484
ABCC1decreases activityEXP 6480464CTDIndomethacin analog results in decreased activity of ABCC1 protein; Indomethacin results in decreased activity of ABCC1 proteinPMID:12142058 PMID:15581599 PMID:15715484 PMID:15916776 PMID:17940500
ABCC1decreases expressionEXP 6480464CTDIndomethacin results in decreased expression of ABCC1 mRNAPMID:18360721
ABCC1multiple interactionsEXP 6480464CTD[Doxorubicin results in decreased expression of ABCC1 mRNA] which results in increased susceptibility to Indomethacin; [Indomethacin affects the activity of ABCC1 protein] which results in increased abundance of fluorexon; Indomethacin affects the reaction [ABCC1 protein results in increased transport of Valproic Acid]; Indomethacin inhibits the reaction [ABCC1 protein affects the export of 5-carboxyfluorescein diacetate]; Indomethacin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]; Indomethacin inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]PMID:15066675 PMID:16101123 PMID:16331495 PMID:16636798 PMID:17940500 PMID:18204840
ABCC1decreases activityISOAbcc1 (Mus musculus)6480464CTDIndomethacin results in decreased activity of ABCC1 proteinPMID:15804283
ABCC1decreases activityISOAbcc1 (Rattus norvegicus)6480464CTDIndomethacin results in decreased activity of ABCC1 proteinPMID:12893836
ABCC1multiple interactionsISOAbcc1 (Rattus norvegicus)6480464CTD[Indomethacin results in decreased activity of ABCC1 protein] which results in increased uptake of VincristinePMID:12893836
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