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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:49603
Term: lapatinib
Definition: A furan that has formula C29H26ClFN4O4S.
Chemical ID: MESH:C490728
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDlapatinib metabolite results in increased expression of NQO1 mRNA

PMID:26958860
multiple interactionsEXP 6480464CTD[CYP3A4 protein results in increased metabolism of lapatinib] which results in increased expression of NQO1 mRNA

PMID:26958860
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.