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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1323402
Species: Homo sapiens
RGD Object: Gene
Symbol: COMMD1
Name: copper metabolism domain containing 1
Acc ID: CHEBI:49553
Term: copper(II) chloride
Definition: An inorganic chloride of copper in which the metal is in the +2 oxidation state.
Chemical ID: MESH:C029892
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
COMMD1decreases expressionEXP 6480464CTDcupric chloride results in decreased expression of COMMD1 mRNA; cupric chloride results in decreased expression of COMMD1 proteinPMID:17211630
COMMD1decreases response to substanceEXP 6480464CTDCOMMD1 protein results in decreased susceptibility to cupric chloridePMID:17211630
COMMD1multiple interactionsEXP 6480464CTDcupric chloride promotes the reaction [COMMD1 protein binds to SOD1 protein]PMID:24691167
COMMD1multiple interactionsISOCommd1 (Rattus norvegicus)6480464CTD[COMMD1 protein co-treated with zinc chloride co-treated with cupric chloride] results in increased expression of SHANK2 protein; [COMMD1 protein co-treated with zinc chloride co-treated with cupric chloride] results in increased expression of SHANK3 proteinPMID:25007851
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