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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:4917
Term: eugenol
Definition: A phenylpropanoid formally derived from guaiacol with an allyl chain substituted para to the hydroxy group.
Chemical ID: MESH:D005054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases metabolic processingISORGD:7362176480464CTDCYP2D6 protein results in increased metabolism of Eugenol

PMID:15576237
multiple interactionsISORGD:7362176480464CTD[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol, [CYP2D6 protein results in increased metabolism of Eugenol] which results in increased abundance of 2-hydroxychavicol, [Eugenol co-treated with Copper co-treated with CYP2D6 protein] results in increased abundance of 8-oxo-7-hydrodeoxyguanosine, bathocuproine inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol], CAT protein inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol], methional inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol]

PMID:15576237
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.