GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp9 | affects expression | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | Etoposide affects the expression of CASP9 protein | PMID:15215046 | Casp9 | increases activity | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | Etoposide results in increased activity of CASP9 protein | PMID:18056177 | Casp9 | increases cleavage | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | Etoposide results in increased cleavage of CASP9 protein | PMID:12925536 PMID:17935137 PMID:21324178 | Casp9 | multiple interactions | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]; [Cisplatin co-treated with Etoposide] results in increased activity of CASP9 protein; CASP8 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP9 protein]; CASP9 mutant form inhibits the reaction [Etoposide results in increased cleavage of BID protein]; Etoposide results in increased cleavage of and results in increased activity of CASP9 protein; HTATIP2 protein promotes the reaction [Etoposide results in increased activity of CASP9 protein]; MYC protein promotes the reaction [Etoposide results in increased cleavage of CASP9 protein]; Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] results in increased activity of CASP9 protein]; nimesulide inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]; TMSB4X protein inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]; wortmannin promotes the reaction [Etoposide results in increased cleavage of CASP9 protein] | PMID:16364925 PMID:16799960 PMID:17935137 PMID:18676776 PMID:21324178 PMID:21745461 PMID:21801448 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |