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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2654
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gadd45a
Name: growth arrest and DNA-damage-inducible, alpha
Acc ID: CHEBI:4911
Term: etoposide
Definition: A furonaphthodioxole that has formula C29H32O13.
Chemical ID: MESH:D005047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gadd45aincreases expressionISOGADD45A (Homo sapiens)6480464CTDEtoposide results in increased expression of GADD45A mRNA; Etoposide results in increased expression of GADD45A proteinPMID:21527772 PMID:29397400 PMID:30177839 PMID:31542801
Gadd45aincreases response to substanceISOGADD45A (Homo sapiens)6480464CTDGADD45A protein results in increased susceptibility to EtoposidePMID:19003803
Gadd45amultiple interactionsISOGADD45A (Homo sapiens)6480464CTDIKBKB protein inhibits the reaction [Etoposide results in increased expression of GADD45A protein]PMID:30177839
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