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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1557448
Species: Mus musculus
RGD Object: Gene
Symbol: Top2b
Name: topoisomerase (DNA) II beta
Acc ID: CHEBI:4911
Term: etoposide
Definition: A furonaphthodioxole that has formula C29H32O13.
Chemical ID: MESH:D005047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top2baffects response to substanceEXP 6480464CTDTOP2B protein affects the susceptibility to Etoposide

PMID:17875725
Top2bdecreases expressionEXP 6480464CTDEtoposide results in decreased expression of TOP2B protein

PMID:10856430
Top2bmultiple interactionsEXP 6480464CTDTOP2B protein affects the reaction [Etoposide results in increased expression of H2AX protein]

PMID:17875725
Top2bdecreases activityISORGD:13506376480464CTDEtoposide results in decreased activity of TOP2B protein

PMID:26198043, PMID:27422292
Top2bdecreases response to substanceISORGD:13506376480464CTDTOP2B protein mutant form results in decreased susceptibility to Etoposide

PMID:16239602
Top2bincreases response to substanceISORGD:13506376480464CTDTOP2B protein mutant form results in increased susceptibility to Etoposide

PMID:15322234
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.