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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307527
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hic1
Name: HIC ZBTB transcriptional repressor 1
Acc ID: CHEBI:4911
Term: etoposide
Definition: A furonaphthodioxole that has formula C29H32O13.
Chemical ID: MESH:D005047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hic1increases expressionISOHIC1 (Homo sapiens)6480464CTDEtoposide results in increased expression of HIC1 mRNAPMID:19491197
Hic1multiple interactionsISOHIC1 (Homo sapiens)6480464CTDE2F1 protein affects the reaction [Etoposide results in increased expression of HIC1 mRNA]; Etoposide promotes the reaction [E2F1 protein binds to HIC1 promoter]PMID:19491197
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