GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Vdr | affects response to substance | ISO | VDR (Homo sapiens) | 6480464 | CTD | VDR gene polymorphism affects the susceptibility to Etoposide; VDR intron polymorphism affects the susceptibility to Etoposide | PMID:12969965 PMID:15713801 | Vdr | increases expression | ISO | VDR (Homo sapiens) | 6480464 | CTD | Etoposide results in increased expression of VDR mRNA | PMID:17716971 | Vdr | multiple interactions | ISO | VDR (Homo sapiens) | 6480464 | CTD | [[Etoposide results in increased expression of TP73 protein] which results in increased expression of VDR protein] which results in increased susceptibility to Calcitriol; TP73 protein affects the reaction [Etoposide results in increased expression of VDR mRNA] | PMID:17716971 | | ||||||||||||||||||||||
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