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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69474
Species: Mus musculus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:49040
Term: ezetimibe
Definition: A beta-lactam that is azetidin-2-one which is substituted at 1, 3, and 4 by p-fluorophenyl, 3-(p-fluorophenyl)-3-hydroxypropyl, and 4-hydroxyphenyl groups, respectively (the 3R,3'S,4S enantiomer).
Chemical ID: MESH:D000069438
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srebf1decreases expressionISOSREBF1 (Homo sapiens)6480464CTDEzetimibe results in decreased expression of SREBF1 mRNAPMID:16177187
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