Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303135
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Npc1l1
Name: NPC1 like intracellular cholesterol transporter 1
Acc ID: CHEBI:49040
Term: ezetimibe
Definition: A beta-lactam that is azetidin-2-one which is substituted at 1, 3, and 4 by p-fluorophenyl, 3-(p-fluorophenyl)-3-hydroxypropyl, and 4-hydroxyphenyl groups, respectively (the 3R,3'S,4S enantiomer).
Chemical ID: MESH:D000069438
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Npc1l1decreases activityISONPC1L1 (Homo sapiens)6480464CTDEzetimibe results in decreased activity of NPC1L1 proteinPMID:28057006
Npc1l1decreases expressionISONPC1L1 (Homo sapiens)6480464CTDEzetimibe results in decreased expression of NPC1L1 mRNAPMID:16177187
Npc1l1decreases response to substanceISONPC1L1 (Homo sapiens)6480464CTDNPC1L1 exon SNP results in decreased susceptibility to EzetimibePMID:15679830
Go Back to source page   Continue to Ontology report