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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737321
Species: Homo sapiens
RGD Object: Gene
Symbol: PROC
Name: protein C, inactivator of coagulation factors Va and VIIIa
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PROCmultiple interactionsEXP 6480464CTD[Ethinyl Estradiol binds to Norethindrone] which results in increased expression of PROC protein; [Ethinyl Estradiol co-treated with dienogest] results in increased activity of PROC protein; [Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased activity of PROC protein; [Ethinyl Estradiol co-treated with Gestodene] affects the expression of PROC protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PROC protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROC; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROC protein; [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased activity of PROC protein; [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of PROC protein; [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of PROC proteinPMID:11720199 PMID:11994571 PMID:12618251 PMID:14551147 PMID:14561536 PMID:15288212 PMID:15669648
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