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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733057
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcr3
Name: C-X-C motif chemokine receptor 3
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcr3increases expressionEXP 6480464CTDEthinyl Estradiol results in increased expression of CXCR3 mRNA; Ethinyl Estradiol results in increased expression of CXCR3 proteinPMID:36329302
Cxcr3multiple interactionsEXP 6480464CTDCXCL10 promotes the reaction [Ethinyl Estradiol results in increased expression of CXCR3 mRNA]; CXCL10 promotes the reaction [Ethinyl Estradiol results in increased expression of CXCR3 protein]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCR3 mRNA]; Digoxin inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCR3 protein]PMID:36329302
Cxcr3multiple interactionsISOCXCR3 (Homo sapiens)6480464CTD[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CXCR3 proteinPMID:10770211
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