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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731890
Species: Mus musculus
RGD Object: Gene
Symbol: Cdk1
Name: cyclin dependent kinase 1
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk1affects expressionEXP 6480464CTDEthinyl Estradiol affects the expression of CDK1 mRNAPMID:17555576
Cdk1increases expressionEXP 6480464CTDEthinyl Estradiol results in increased expression of CDK1 mRNAPMID:12072388 PMID:16174780 PMID:17942748 PMID:24096037
Cdk1multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDK1 mRNAPMID:17942748
Cdk1affects expressionISOCdk1 (Rattus norvegicus)6480464CTDEthinyl Estradiol affects the expression of CDK1 mRNAPMID:17351261
Cdk1increases expressionISOCdk1 (Rattus norvegicus)6480464CTDEthinyl Estradiol results in increased expression of CDK1 mRNAPMID:15576828 PMID:16174780 PMID:24096037
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