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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70503
Species: Mus musculus
RGD Object: Gene
Symbol: Tfrc
Name: transferrin receptor
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tfrcmultiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TFRC mRNAPMID:17942748
Tfrcmultiple interactionsISOTFRC (Homo sapiens)6480464CTD[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in decreased expression of TFRC proteinPMID:16002536
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