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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621869
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rapgef3
Name: Rap guanine nucleotide exchange factor 3
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDEthinyl Estradiol affects the expression of RAPGEF3 mRNA

PMID:20170705, PMID:26865667
affects expressionISORGD:13512166480464CTDEthinyl Estradiol affects the expression of RAPGEF3 mRNA

PMID:20170705, PMID:26865667
decreases expressionISORGD:13512166480464CTDEthinyl Estradiol results in decreased expression of RAPGEF3 mRNA

PMID:18936297
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.