Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621389
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slco1a4
Name: solute carrier organic anion transporter family, member 1a4
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slco1a4decreases expressionEXP 15090804RGD17alpha-ethynylestradiol decreases expression of Slco1a4 mRNA and protein in primary hepatocytes; decreases expression of mRNA in liver 
Slco1a4decreases expressionEXP 6480464CTDEthinyl Estradiol results in decreased expression of SLCO1A2 mRNA; Ethinyl Estradiol results in decreased expression of SLCO1A2 protein; Ethinyl Estradiol results in decreased expression of SLCO1A4 mRNA; Ethinyl Estradiol results in decreased expression of SLCO1A4 proteinPMID:12507762 PMID:27090119 PMID:27743861
Slco1a4multiple interactionsEXP 6480464CTD4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 protein]; Chenodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]; dorsomorphin inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]; dorsomorphin inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 protein]; Fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 protein]; GW 4064 inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]; NR1H4 protein inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]; PRKAA1 protein inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]PMID:27090119 PMID:27743861
Slco1a4decreases expressionISOSLCO1A2 (Homo sapiens)6480464CTDEthinyl Estradiol results in decreased expression of SLCO1A2 mRNAPMID:27743861
Slco1a4decreases expressionISOSlco1a4 (Mus musculus)6480464CTDEthinyl Estradiol results in decreased expression of SLCO1A4 mRNAPMID:34058177
Slco1a4multiple interactionsISOSlco1a4 (Mus musculus)6480464CTD[Ethinyl Estradiol co-treated with Metformin] results in decreased expression of SLCO1A4 mRNAPMID:34058177
Go Back to source page   Continue to Ontology report