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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620950
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a7c
Name: UDP glucuronosyltransferase 1 family, polypeptide A7C
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a7cincreases expressionEXP 6480464CTDEthinyl Estradiol results in increased expression of UGT1A7 mRNA; Ethinyl Estradiol results in increased expression of UGT1A8 mRNAPMID:15834898 PMID:17557909
Ugt1a7cmultiple interactionsEXP 6480464CTD[Ethinyl Estradiol co-treated with Spironolactone] results in increased activity of UGT1A7 protein; [Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of UGT1A7 proteinPMID:17686906
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