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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619554
Species: Homo sapiens
RGD Object: Gene
Symbol: CD36
Name: CD36 molecule (CD36 blood group)
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CD36affects expressionISOCd36 (Mus musculus)6480464CTDEthinyl Estradiol affects the expression of CD36 mRNAPMID:17555576
CD36decreases expressionISOCd36 (Mus musculus)6480464CTDEthinyl Estradiol results in decreased expression of CD36 mRNAPMID:17942748 PMID:29112739
CD36multiple interactionsISOCd36 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CD36 mRNA; ESR1 gene mutant form inhibits the reaction [Ethinyl Estradiol results in decreased expression of CD36 mRNA]PMID:17942748 PMID:29112739
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