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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61914
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tfpi
Name: tissue factor pathway inhibitor
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tfpidecreases activityEXP 6480464CTDEthinyl Estradiol results in decreased activity of TFPI proteinPMID:15857755
Tfpidecreases expressionEXP 6480464CTDEthinyl Estradiol results in decreased expression of TFPI mRNA; Ethinyl Estradiol results in decreased expression of TFPI proteinPMID:15857755 PMID:17557909
Tfpimultiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased activity of TFPI protein]; norethindrone acetate promotes the reaction [Ethinyl Estradiol results in decreased activity of TFPI protein]PMID:15857755
Tfpimultiple interactionsISOTFPI (Homo sapiens)6480464CTDEthinyl Estradiol results in decreased expression of and results in decreased secretion of TFPI proteinPMID:17029634
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