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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61846
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Psma4
Name: proteasome 20S subunit alpha 4
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Psma4decreases expressionEXP 6480464CTDEthinyl Estradiol results in decreased expression of PSMA4 mRNAPMID:12655037
Psma4increases expressionEXP 6480464CTDEthinyl Estradiol results in increased expression of PSMA4 mRNAPMID:16174780 PMID:24096037
Psma4affects expressionISOPsma4 (Mus musculus)6480464CTDEthinyl Estradiol affects the expression of PSMA4 mRNAPMID:17555576
Psma4increases expressionISOPsma4 (Mus musculus)6480464CTDEthinyl Estradiol results in increased expression of PSMA4 mRNAPMID:16174780 PMID:17942748 PMID:24096037
Psma4multiple interactionsISOPsma4 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMA4 mRNAPMID:17942748
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