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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3776
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sult1e1
Name: sulfotransferase family 1E member 1
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sult1e1affects sulfationISOSULT1E1 (Homo sapiens)6480464CTDEthinyl Estradiol affects the sulfation of SULT1E1 proteinPMID:11358677
Sult1e1decreases activityISOSULT1E1 (Homo sapiens)6480464CTDEthinyl Estradiol results in decreased activity of SULT1E1 proteinPMID:16914110
Sult1e1increases sulfationISOSULT1E1 (Homo sapiens)6480464CTDSULT1E1 protein results in increased sulfation of Ethinyl EstradiolPMID:14570759 PMID:15483196
Sult1e1multiple interactionsISOSULT1E1 (Homo sapiens)6480464CTD[2,6-dichloro-4-nitrophenol co-treated with SULT1E1 protein] results in decreased sulfation of Ethinyl Estradiol; [Estrone co-treated with SULT1E1 protein] results in decreased sulfation of Ethinyl Estradiol; [Quercetin co-treated with SULT1E1 protein] results in decreased sulfation of Ethinyl Estradiol; Ethanol inhibits the reaction [SULT1E1 protein results in increased sulfation of Ethinyl Estradiol]PMID:14570759 PMID:15483196
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