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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2411
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Crp
Name: C-reactive protein
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Crpaffects expressionISOCrp (Mus musculus)6480464CTDEthinyl Estradiol affects the expression of CRP mRNAPMID:14976129
Crpincreases expressionISOCRP (Homo sapiens)6480464CTDEthinyl Estradiol results in increased expression of CRP proteinPMID:10959719
Crpmultiple interactionsISOCRP (Homo sapiens)6480464CTD[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CRP protein; [Ethinyl Estradiol co-treated with Desogestrel] results in increased expression of CRP protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of CRP protein; [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of CRP protein; [Ethinyl Estradiol co-treated with norethindrone acetate] results in increased expression of CRP protein; [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of CRP protein; Simvastatin inhibits the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in increased expression of CRP protein]PMID:12616983 PMID:14557435 PMID:15769986 PMID:16982228 PMID:17105841 PMID:17903073
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