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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh1a1
Name: aldehyde dehydrogenase 1 family, member A1
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh1a1affects expressionEXP 6480464CTDEthinyl Estradiol affects the expression of ALDH1A1 mRNAPMID:20170705 PMID:26865667
Aldh1a1decreases expressionEXP 6480464CTDEthinyl Estradiol results in decreased expression of ALDH1A1 mRNAPMID:12655037 PMID:15834898 PMID:17557909
Aldh1a1affects expressionISOAldh1a1 (Mus musculus)6480464CTDEthinyl Estradiol affects the expression of ALDH1A1 mRNAPMID:17555576
Aldh1a1affects expressionISOALDH1A1 (Homo sapiens)6480464CTDEthinyl Estradiol affects the expression of ALDH1A1 mRNAPMID:20170705 PMID:26865667
Aldh1a1decreases expressionISOALDH1A1 (Homo sapiens)6480464CTDEthinyl Estradiol results in decreased expression of ALDH1A1 mRNAPMID:18936297
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