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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1603716
Species: Homo sapiens
RGD Object: Gene
Symbol: CCR2
Name: C-C motif chemokine receptor 2
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCR2decreases expressionISOCcr2 (Mus musculus)6480464CTDEthinyl Estradiol results in decreased expression of CCR2 mRNAPMID:12538720 PMID:15885639
CCR2increases expressionISOCcr2 (Rattus norvegicus)6480464CTDEthinyl Estradiol results in increased expression of CCR2 mRNAPMID:15834898
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