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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558311
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2b10
Name: cytochrome P450, family 2, subfamily b, polypeptide 10
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2b10decreases expressionEXP 6480464CTDEthinyl Estradiol results in decreased expression of CYP2B10 mRNAPMID:27818225
Cyp2b10increases expressionEXP 6480464CTDEthinyl Estradiol results in increased expression of CYP2B10 mRNAPMID:12948398
Cyp2b10affects metabolic processingISOCYP2B6 (Homo sapiens)6480464CTDCYP2B6 protein affects the metabolism of Ethinyl EstradiolPMID:16485904
Cyp2b10multiple interactionsISOCYP2B6 (Homo sapiens)6480464CTD[Ethinyl Estradiol co-treated with NADP] results in decreased activity of CYP2B6 proteinPMID:11805216 PMID:16485904
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