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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553791
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt2b1
Name: UDP glucuronosyltransferase 2 family, polypeptide B1
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt2b1decreases activityISOUgt2b1 (Rattus norvegicus)6480464CTDEthinyl Estradiol results in decreased activity of UGT2B1 proteinPMID:12663690
Ugt2b1decreases expressionISOUgt2b1 (Rattus norvegicus)6480464CTDEthinyl Estradiol results in decreased expression of UGT2B1 proteinPMID:12663690
Ugt2b1increases glucuronidationISOUgt2b1 (Rattus norvegicus)6480464CTDUGT2B1 protein results in increased glucuronidation of Ethinyl EstradiolPMID:15921999
Ugt2b1multiple interactionsISOUgt2b1 (Rattus norvegicus)6480464CTDUrsodeoxycholic Acid promotes the reaction [Ethinyl Estradiol results in decreased activity of UGT2B1 protein]; Ursodeoxycholic Acid promotes the reaction [Ethinyl Estradiol results in decreased expression of UGT2B1 protein]PMID:12663690
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