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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11429
Species: Mus musculus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfdecreases expressionEXP 6480464CTDEthinyl Estradiol results in decreased expression of TNF mRNAPMID:15885639
Tnfdecreases secretionEXP 6480464CTDEthinyl Estradiol results in decreased secretion of TNF proteinPMID:12538720 PMID:15885639
Tnfincreases expressionEXP 6480464CTDEthinyl Estradiol results in increased expression of TNF mRNA; Ethinyl Estradiol results in increased expression of TNF proteinPMID:27818225
Tnfmultiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TNF mRNA; SRT1720 inhibits the reaction [Ethinyl Estradiol results in increased expression of TNF mRNA]; SRT1720 inhibits the reaction [Ethinyl Estradiol results in increased expression of TNF protein]PMID:17942748 PMID:27818225
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTD[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of TNF protein; [Ethinyl Estradiol co-treated with Lipopolysaccharides] results in increased expression of TNF proteinPMID:15769986 PMID:36113621
Tnfmultiple interactionsISOTnf (Rattus norvegicus)6480464CTDEthinyl Estradiol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]PMID:16735947
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