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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10996
Species: Mus musculus
RGD Object: Gene
Symbol: Nos2
Name: nitric oxide synthase 2, inducible
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos2decreases expressionEXP 6480464CTDEthinyl Estradiol results in decreased expression of NOS2 mRNAPMID:29935216
Nos2multiple interactionsEXP 6480464CTD[Ethinyl Estradiol co-treated with Streptozocin] results in decreased expression of NOS2 protein; Streptozocin inhibits the reaction [Ethinyl Estradiol results in decreased expression of NOS2 mRNA]PMID:29935216
Nos2multiple interactionsISONOS2 (Homo sapiens)6480464CTD[Ethinyl Estradiol co-treated with drospirenone] results in decreased expression of NOS2 mRNAPMID:19631796
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