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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10118
Species: Mus musculus
RGD Object: Gene
Symbol: Agt
Name: angiotensinogen
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtincreases expressionISOAGT (Homo sapiens)6480464CTDEthinyl Estradiol results in increased expression of AGT proteinPMID:11095476 PMID:17374706
Agtmultiple interactionsISOAGT (Homo sapiens)6480464CTD[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of AGT protein; [Ethinyl Estradiol co-treated with ST 1435] results in increased expression of AGT protein; AGT gene polymorphism promotes the reaction [Ethinyl Estradiol results in increased activity of REN protein]; AGT gene polymorphism promotes the reaction [Ethinyl Estradiol results in increased expression of AGT protein]; AGT gene polymorphism promotes the reaction [Ethinyl Estradiol results in increased secretion of AGT protein]PMID:11095476 PMID:17519148
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