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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348637
Species: Homo sapiens
RGD Object: Gene
Symbol: DCX
Name: doublecortin
Acc ID: CHEBI:4887
Term: ethosuximide
Definition: A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.
Chemical ID: MESH:D005013
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DCXincreases expressionISODcx (Rattus norvegicus)6480464CTDEthosuximide results in increased expression of DCX mRNAPMID:26420483
DCXmultiple interactionsISODcx (Rattus norvegicus)6480464CTDEthosuximide inhibits the reaction [APP protein modified form results in decreased expression of DCX mRNA]PMID:26420483
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