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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11492
Species: Mus musculus
RGD Object: Gene
Symbol: Wnt3
Name: wingless-type MMTV integration site family, member 3
Acc ID: CHEBI:4887
Term: ethosuximide
Definition: A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.
Chemical ID: MESH:D005013
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Wnt3increases expressionISOWnt3 (Rattus norvegicus)6480464CTDEthosuximide results in increased expression of WNT3 mRNAPMID:26420483
Wnt3multiple interactionsISOWnt3 (Rattus norvegicus)6480464CTDEthosuximide inhibits the reaction [APP protein modified form results in decreased expression of WNT3 mRNA]PMID:26420483
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