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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732257
Species: Homo sapiens
RGD Object: Gene
Symbol: GSTP1
Name: glutathione S-transferase pi 1
Acc ID: CHEBI:48843
Term: disodium selenite
Definition: An inorganic sodium salt composed of sodium and selenite ions in a 2:1 ratio.
Chemical ID: MESH:D018038
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSTP1decreases methylationEXP 6480464CTDSodium Selenite results in decreased methylation of GSTP1 promoterPMID:18676679
GSTP1increases expressionEXP 6480464CTDSodium Selenite results in increased expression of GSTP1 mRNA; Sodium Selenite results in increased expression of GSTP1 proteinPMID:18676679
GSTP1multiple interactionsEXP 6480464CTDSodium Selenite affects the reaction [H3-4 protein modified form binds to GSTP1 promoter]; Sodium Selenite inhibits the reaction [GSTP1 protein SNP binds to and results in increased glutathionylation of Dinitrochlorobenzene]PMID:18676679 PMID:22401947
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