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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730872
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD2
Name: superoxide dismutase 2
Acc ID: CHEBI:48843
Term: disodium selenite
Definition: An inorganic sodium salt composed of sodium and selenite ions in a 2:1 ratio.
Chemical ID: MESH:D018038
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD2decreases response to substanceEXP 6480464CTDSOD2 protein results in decreased susceptibility to Sodium SelenitePMID:15130278 PMID:15650415
SOD2increases expressionEXP 6480464CTDSodium Selenite results in increased expression of SOD2 proteinPMID:21215776
SOD2decreases expressionISOSod2 (Mus musculus)6480464CTDSodium Selenite results in decreased expression of SOD2 mRNA; Sodium Selenite results in decreased expression of SOD2 proteinPMID:15650415
SOD2multiple interactionsISOSod2 (Mus musculus)6480464CTDSodium Selenite inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of SOD2 mRNA]PMID:15650415
SOD2multiple interactionsISOSod2 (Rattus norvegicus)6480464CTD[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of SOD2 mRNAPMID:23859036
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