GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gpx4 | multiple interactions | EXP | | 6480464 | CTD | Sodium Selenite inhibits the reaction [Cadmium Chloride results in decreased expression of GPX4 mRNA] | PMID:20643113 | Gpx4 | affects activity | ISO | GPX4 (Homo sapiens) | 6480464 | CTD | Sodium Selenite affects the activity of GPX4 protein polymorphism | PMID:18400727 | Gpx4 | affects expression | ISO | GPX4 (Homo sapiens) | 6480464 | CTD | Sodium Selenite affects the expression of GPX4 protein polymorphism | PMID:18400727 | Gpx4 | affects response to substance | ISO | GPX4 (Homo sapiens) | 6480464 | CTD | GPX4 gene SNP affects the susceptibility to Sodium Selenite | PMID:18400727 | Gpx4 | increases expression | ISO | GPX4 (Homo sapiens) | 6480464 | CTD | Sodium Selenite results in increased expression of GPX4 mRNA; Sodium Selenite results in increased expression of GPX4 protein | PMID:14642406 PMID:18514395 PMID:37716422 | Gpx4 | multiple interactions | ISO | GPX4 (Homo sapiens) | 6480464 | CTD | alpha-Tocopherol inhibits the reaction [Sodium Selenite results in increased expression of GPX4 mRNA]; Arachidonic Acid promotes the reaction [Sodium Selenite results in increased expression of and results in increased activity of GPX4 protein]; Docosahexaenoic Acids inhibits the reaction [Sodium Selenite results in increased expression of and results in increased activity of GPX4 protein]; Docosahexaenoic Acids promotes the reaction [Sodium Selenite results in increased expression of GPX4 mRNA]; GPX4 gene SNP inhibits the reaction [Sodium Selenite results in increased activity of GPX1 protein]; GPX4 gene SNP inhibits the reaction [Sodium Selenite results in increased activity of GPX3 protein]; GPX4 gene SNP inhibits the reaction [Sodium Selenite results in increased expression of GPX1 protein]; GPX4 gene SNP inhibits the reaction [Sodium Selenite results in increased expression of GPX3 protein]; IL1B protein promotes the reaction [Sodium Selenite results in increased expression of and results in increased activity of GPX4 protein]; IL1B protein promotes the reaction [Sodium Selenite results in increased expression of GPX4 mRNA]; Linoleic Acids, Conjugated promotes the reaction [Sodium Selenite results in increased expression of GPX4 mRNA]; Sodium Selenite inhibits the reaction [Matrines results in decreased expression of GPX4 protein]; Sodium Selenite results in increased expression of and results in increased activity of GPX4 protein; TNF protein affects the reaction [Sodium Selenite results in increased activity of GPX4 protein]; TNF protein affects the reaction [Sodium Selenite results in increased expression of GPX4 mRNA] | PMID:14642406 PMID:18400727 PMID:37716422 | Gpx4 | multiple interactions | ISO | Gpx4 (Mus musculus) | 6480464 | CTD | Sodium Selenite inhibits the reaction [Selenium deficiency results in decreased expression of GPX4 protein] | PMID:34970773 | | ||||||||||||||||||||||
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