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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:48843
Term: disodium selenite
Definition: An inorganic sodium salt composed of sodium and selenite ions in a 2:1 ratio.
Chemical ID: MESH:D018038
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosincreases expressionEXP 6480464CTDSodium Selenite results in increased expression of FOS proteinPMID:16944776
Fosmultiple interactionsEXP 6480464CTDSodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]PMID:11769627
Fosincreases expressionISOFos (Mus musculus)6480464CTDSodium Selenite results in increased expression of FOS mRNAPMID:16542727 PMID:18449455
Fosincreases expressionISOFOS (Homo sapiens)6480464CTDSodium Selenite results in increased expression of FOS mRNAPMID:18175754
Fosmultiple interactionsISOFos (Mus musculus)6480464CTDButhionine Sulfoximine inhibits the reaction [Sodium Selenite results in increased expression of FOS mRNA]; Glutathione affects the reaction [Sodium Selenite results in increased expression of FOS mRNA]PMID:18449455
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTD[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of FOS mRNA; [Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of FOS proteinPMID:28757135
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