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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349200
Species: Homo sapiens
RGD Object: Gene
Symbol: GSTA1
Name: glutathione S-transferase alpha 1
Acc ID: CHEBI:4876
Term: etacrynic acid
Definition: An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Chemical ID: MESH:D004976
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSTA1affects metabolic processingEXP 6480464CTDGSTA1 protein affects the metabolism of Ethacrynic Acid analogPMID:12781783
GSTA1decreases response to substanceEXP 6480464CTDGSTA1 protein results in decreased susceptibility to Ethacrynic AcidPMID:1985777
GSTA1increases expressionISOGsta1 (Rattus norvegicus)6480464CTDEthacrynic Acid results in increased expression of GSTA1 mRNAPMID:9799558
GSTA1multiple interactionsISOGsta1 (Rattus norvegicus)6480464CTD[GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Ethacrynic AcidPMID:9877184
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