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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2348
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrna7
Name: cholinergic receptor nicotinic alpha 7 subunit
Acc ID: CHEBI:48723
Term: (-)-lobeline
Definition: An optically active piperidine alkaloid having a 2-oxo-2-phenylethyl substituent at the 2-position and a 2-hydroxy-2-phenylethyl group at the 6-position.
Chemical ID: MESH:D008120
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna7affects response to substanceISORGD:7368476480464CTDCHRNA7 protein mutant form affects the susceptibility to Lobeline

PMID:10082212
Chrna7multiple interactionsISORGD:7368476480464CTDLobeline binds to and results in decreased activity of CHRNA7 protein Lobeline binds to and results in increased activity of CHRNA7 protein mutant form

PMID:10082212
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